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Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

《医学前沿（英文）》 2007年 第1卷 第4期   页码 356-358 doi: 10.1007/s11684-007-0068-5

摘要： The effect of hyperlipidemia and inflammation on endothelial functions was studied. The enrolled included control (basic chow), hyperlipidemia and fenofibrate-treated groups (high fat diet). The hyperlipidemia model was set up by four-week atherogenic diet, followed by a 16-week treatment in the fenofibrate-treated group (fenofibrate 40 mg/kg every day) and without treatment in the hyperlipidemia group, respectively. In the 20th week, serum lipid level and NO levels were measured, and the expression of vascular cell adhesion molecule-1 (VCAM-1) and cell adhesiveness in aortic endothelia observed by computer-aided system. Compared with the control group, hyperlipidemia rats showed lower levels of NO and ncreases in leukocyte accumulation on the endothelial surface, also stronger and more extensive endothelial expression of VCAM-1. In fenofibrate-treated group, the expression of VCAM-1 and leukocyte accumulation on the endothelial surface was decreased, while serum levels of NO were increased as compared with hyperli pidemia group. Hyperlipidemia can inhibit the NO activity and promote the damage of VACA-1 to aortic endothelia. Fenofibrate can effectively prevent the pathogenesis of atherosclerosis by restoring NO levels and down-regulating the VCAM-1 expression.

关键词： endothelial     16-week treatment     leukocyte accumulation     mg/kg     NO    

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Coronary leukocyte activation in relation to progression of coronary artery disease

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 85-90 doi: 10.1007/s11684-016-0435-1

摘要：

Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.

关键词： coronary artery disease     inflammation     integrin     myeloperoxidase     leukocyte activation    

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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

null

《医学前沿（英文）》 2013年 第7卷 第3期   页码 306-315 doi: 10.1007/s11684-013-0279-x

摘要：

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34+positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCT without ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT.

关键词： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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Genotype variations in accumulation of cadmium and lead in celery (

Kun ZHANG, Jianbing WANG, Zhongyi YANG, Guorong XIN, Jiangang YUAN, Junliang XIN, Charlie HUANG

《环境科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 85-96 doi: 10.1007/s11783-012-0399-3

摘要： To help reduce risks of heavy metal pollution, two pot experiments were conducted to investigate the variations, transfer potential, and stability of Cadmium (Cd) and Lead (Pb) accumulations in celery ( L.) and to screen for low Cd and Pb accumulative cultivars. The maximum differences in shoot Cd concentration were 4.7-fold under low-Cd exposure and 3.3-fold under high-Cd exposure. These genotype variations in Cd accumulation are sufficiently large to help reduce Cd contamination risk in soil by using the Low-Cd-Accumulative genotypes. Cd accumulation of the Low-Cd-Accumulative genotypes is significantly positive correlated with Pb accumulation. Evidence obtained proves that Cd and Pb accumulations in celery are stable and genotype-dependent at the cultivar level. The presence of high-Pb contamination in soil promoted Cd accumulation in shoots of celery. Celery is considered a species with high risks in Cd pollution and low risks in Pb pollution. Among the tested cultivars, cv. Shuanggangkangbing (SGKB) had the lowest shoot Cd and Pb accumulating abilities, and thus is the most important material for breeding of pollution-safe cultivars (PSCs) to minimize Cd and Pb accumulations in celery.

关键词： cadmium (Cd) accumulation     lead (Pb) accumulation     celery     genotype variation     food safety    

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recovery between event-free patients receiving haploidentical allografts and those receiving human leukocyte

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 153-163 doi: 10.1007/s11684-017-0548-1

摘要：

To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo-SCT) and without showing any of the following events: poor graft function, grades II?IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3+ T cells, CD8+ T cells, and CD19+ B cells, and very slow in CD4+ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.

关键词： immune reconstitution     hematopoietic stem cell transplantation     event-free patients     reference range    

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Comparison of growth and lipid accumulation properties of two oleaginous microalgae under different nutrient

Qiao ZHANG,Yu HONG

《环境科学与工程前沿（英文）》 2014年 第8卷 第5期   页码 703-709 doi: 10.1007/s11783-014-0649-x

摘要： This study compared the growth and lipid accumulation properties of two oleaginous microalgae, namely, sp. LX1 and sp. HQ, under different nutrient conditions. Both algal species obtained the highest biomass, lipid content and lipid yield under low-nutrient conditions (mBG11 medium). The biomass, lipid content and lipid yield of sp. LX1 were 0.42 g·L , 22.5% and 93.8 mg·L , respectively. These values were relatively higher than those of sp. HQ (0.30 g·L , 17.1% and 51.3 mg·L , respectively). These algae were then cultivated in an SE medium that contained more nutrients; as a result, the biomass and lipid yield of sp. LX1 reduced more significantly than those of sp. HQ. Opposite results were observed in lipid and triacylglycerols (TAGs) contents. The cell sizes of both algal species under low-nutrient conditions were larger than those under high-nutrient conditions. sp. HQ cells did not aggregate, but sp. LX1 cells flocculated easily, particularly under low-nutrient conditions. In summary, low-nutrient conditions favour the growth and lipid production of both algae, but sp. LX1 outperforms sp. HQ.

关键词： Scenedesmus sp. LX1     Chlorella sp. HQ     growth rate     algal biomass     lipid accumulation     triacylglycerols (TAGs)    

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Erratum to: Meter-scale variation within a single transect demands attention to taxon accumulation curves

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-022-1560-5

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Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine

《环境科学与工程前沿（英文）》 2022年 第16卷 第5期 doi: 10.1007/s11783-022-1543-6

摘要：

● Riverine microbiomes exhibited hyperlocal variation within a single transect.

关键词： Microbiome     Freshwater     Taxon accumulation curve     Community assembly    

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Experimental study of nitrite accumulation in pre-denitrification biological nitrogen removal process

WU Xuelei, CHEN Lunqiang, PENG Yongzhen, WANG Pu, WANG Yayi

《环境科学与工程前沿（英文）》 2008年 第2卷 第2期   页码 236-240 doi: 10.1007/s11783-008-0008-x

摘要： The effect of dissolved oxygen (DO) concentration on nitrite accumulation was investigated in a pilot-scale pre-denitrification process at room temperature for 100 days. In the first 10 days, due to the instability of the system, the DO concentration fluctuated between 1.0 and 2.0 mg/L. In the next 14 days, the DO concentration was kept at 0.5 mg/L and nitrite accumulation occurred, with the average nitrite accumulation rate at 91%. From the 25th day, the DO concentration was increased to 2.0 mg/L to destroy the nitrite accumulation, but nitrite accumulation rate was still as high as 90%. From the 38th day the nitrite accumulation rate decreased to 15%–30% linearly. From the 50th day, DO concentration was decreased to 0.5 mg/L to resume nitrite accumulation. Until the 83rd day the nitrite accumulation rate began to increase to 80%. Dissolved oxygen was the main cause of nitrite accumulation, taking into account other factors such as pH, free ammonia concentration, temperature, and sludge retention time. Because of the different affinity for oxygen between nitrite oxidizing bacteria and ammonia oxidizing bacteria when DO concentration was kept at 0.5 mg/L, nitrite accumulation occurred.
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Simultaneous denitrifying phosphorus accumulation in a sequencing batch reactor

YUAN Linjiang, HAN Wei, WANG Lei, YANG Yongzhe, WANG Zhiying

《环境科学与工程前沿（英文）》 2007年 第1卷 第1期   页码 23-27 doi: 10.1007/s11783-007-0004-6

摘要： In order to achieve simultaneous nitrogen and phosphorus removal in the biological treatment process, denitrifying phosphorus accumulation (DNPA) and its affecting factors were studied in a sequencing batch reactor (SBR) with synthetic wastewater. The results showed that when acetate was used as the sole carbon resource in the influent, the sludge acclimatized under anaerobic/aerobic operation had good phosphorus removal ability. Denitrifying phosphorus accumulation was observed soon when fed with nitrate instead of aeration following the anaerobic stage, which is a vital premise to DNPA. If DNPA sludge is fed with nitrate prior to the anaerobic stage, the DNPA would weaken or even disappear. At the high concentration of nitrate fed in the anoxic stage, the longer anoxic time needed, the better the DNPA was. Induced DNPA did not disappear even though an aerobic stage followed the anoxic stage, but the shorter the aerobic stage lasted, the higher the proportions of phosphorus removal via DNPA to total removal.

关键词： SBR     synthetic wastewater     Induced DNPA     resource     removal ability    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

《环境科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 226-238 doi: 10.1007/s11783-013-0582-4

摘要： Subcellular distributions and chemical forms of cadmium (Cd) in the leaves, stems and roots were investigated in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.). Root cell wall played a key role in limiting soil Cd from entering the protoplast, especially in the low-Cd cultivars. The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivars in cell wall fraction, chloroplast/trophoplast fraction, organelle fraction and soluble fraction. In low-Cd cultivars, which were more sensitive and thus had greater physiological needs of Cd detoxification than high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd. Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd translocation from root to shoot, which might be one of the mechanisms that led to the differences in shoot Cd accumulation between the two types of cultivars. Furthermore, the formation of Cd-phosphate complexes (extracted by 2% HAc) was also involved in Cd detoxification within the roots of pakchoi under high Cd stress, suggesting that the mechanisms of Cd detoxification might be different between low- and high-Cd cultivars.

关键词： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)     subcellular distribution     chemical forms    

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Heavy metal accumulation and phytostabilization potential of dominant plant species growing on manganese

YANG Shengxiang,LIANG Shichu,YI Langbo,XU Bibo,CAO Jianbing,GUO Yifeng,ZHOU Yu

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 394-404 doi: 10.1007/s11783-013-0602-4

摘要： Screening plants that are hypertolerant to and excluders of certain heavy metals plays a fundamental role in a remediation strategy for metalliferous mine tailings. A field survey of terrestrial higher plants growing on Mn mine tailings at Huayuan, Hunan Province, China was conducted to identify candidate species for application in phytostabilization of the tailings in this region. In total, 51 species belonging to 21 families were recorded and the 12 dominant plants were investigated for their potential in phytostabilization of heavy metals. Eight plant species, , , , , , , , and accumulated much lower concentrations of heavy metals in shoots and roots than the associated soils and bioconcentration factors (BFs) for Cd, Mn, Pb and Zn were all<1, demonstrating a high tolerance to heavy metals and poor metals translocation ability. The field investigation also found that these species grew fast, accumulated biomass rapidly and developed a vegetation cover in a relatively short time. Therefore, they are good candidates for phytostabilization purposes and could be used as pioneer species in phytoremediation of Mn mine tailings in this region of South China.

关键词： Mn mine tailings     heavy metal accumulation     phytostabilization    

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HLA and lung transplantation

Liya Ju, Caroline Suberbielle, Xiaofan Li, Nuala Mooney, Dominique Charron

《医学前沿（英文）》 2019年 第13卷 第3期   页码 298-313 doi: 10.1007/s11684-018-0636-x

摘要： Lung transplantation is increasingly practiced for patients with end-stage lung disease. The successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies, mainly directed against the protein products of the HLA complex of the organ donor. While the association between antibody mediated rejection and allograft damage has been well established in renal and heart transplantation, it has not yet been well characterized in lung transplantation. This review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class I and II antigens. The role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or post-transplant circulating antibodies. Finally, potential mechanisms, which may act individually or in combination, of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II     lung transplantation     mismatch     obliterans bronchiolitis     alloantibody     antibody mediated rejection    

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 507-516 doi: 10.1007/s11684-016-0475-6

摘要：

Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein≥1.0 g/24 h than in patients with urine protein<1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR= 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.

关键词： DQB1     human leukocyte antigen (HLA)     IgA nephropathy     haplotype     association study    

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Cadmium tolerance and accumulation in fifteen wetland plant species from cadmium-polluted water in constructed

Jianguo LIU,Wen ZHANG,Peng QU,Mingxin WANG

《环境科学与工程前沿（英文）》 2016年 第10卷 第2期   页码 262-269 doi: 10.1007/s11783-014-0746-x

摘要： Variations in cadmium (Cd) tolerances and accumulations among fifteen wetland plant species in moderately (0.5 mg·L ) and heavily (1.0 mg·L ) Cd-polluted wastewaters were investigated in constructed wetlands. Cd removal efficiencies from the wastewaters were more than 90%, and 23.5% and 16.8% of the Cd in the water accumulated in wetland plants for 0.5 and 1.0 mg·L Cd treatments, respectively. The variations among the plant species were 29.4-fold to 48.7-fold in plant biomasses, 5.4-fold to 21.9-fold in Cd concentrations, and 13.8-fold to 29.6-fold in Cd accumulations. The plant species were also largely diversified in terms of Cd tolerance. Some species were tolerant of heavy Cd stress, and some others were sensitive to moderate Cd level. Four wetland plant species were selected for the treatment of Cd-polluted wastewater for their high Cd accumulating abilities and relative Cd tolerances. Plant Cd quantity accumulations are correlated positively and significantly ( <0.05) with plant biomasses and correlated positively but insignificantly ( >0.05) with plant Cd concentrations. The results indicate that the Cd accumulation abilities of wetland plant species are determined mainly by their biomasses and Cd tolerances in growth, which should be the first criteria in selecting wetland plant species for the treating Cd-polluted wastewaters. Cd concentration in the plants may be the second consideration.

关键词： cadmium (Cd)     wastewater treatment     wetland plant     selection     index    

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标题 作者 时间 类型 操作

Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

期刊论文

Coronary leukocyte activation in relation to progression of coronary artery disease

null

期刊论文

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

null

期刊论文

Genotype variations in accumulation of cadmium and lead in celery (

Kun ZHANG, Jianbing WANG, Zhongyi YANG, Guorong XIN, Jiangang YUAN, Junliang XIN, Charlie HUANG

期刊论文

recovery between event-free patients receiving haploidentical allografts and those receiving human leukocyte

null

期刊论文

Comparison of growth and lipid accumulation properties of two oleaginous microalgae under different nutrient

Qiao ZHANG,Yu HONG

期刊论文

Erratum to: Meter-scale variation within a single transect demands attention to taxon accumulation curves

期刊论文

Meter-scale variation within a single transect demands attention to taxon accumulation curves in riverine

期刊论文

Experimental study of nitrite accumulation in pre-denitrification biological nitrogen removal process

WU Xuelei, CHEN Lunqiang, PENG Yongzhen, WANG Pu, WANG Yayi

期刊论文

Simultaneous denitrifying phosphorus accumulation in a sequencing batch reactor

YUAN Linjiang, HAN Wei, WANG Lei, YANG Yongzhe, WANG Zhiying

期刊论文

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

期刊论文

Heavy metal accumulation and phytostabilization potential of dominant plant species growing on manganese

YANG Shengxiang,LIANG Shichu,YI Langbo,XU Bibo,CAO Jianbing,GUO Yifeng,ZHOU Yu

期刊论文

HLA and lung transplantation

Liya Ju, Caroline Suberbielle, Xiaofan Li, Nuala Mooney, Dominique Charron

期刊论文

DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

null

期刊论文

Cadmium tolerance and accumulation in fifteen wetland plant species from cadmium-polluted water in constructed

Jianguo LIU,Wen ZHANG,Peng QU,Mingxin WANG

期刊论文